Assistant Professor of Biology
BS: Seoul National University, Korea
MS, PhD: Korea Advanced Institute of Science and Technology, Korea
Postdoc: Baylor College of Medicine, Houston
Major area of research -- Drosophila Genetics
Courses currently teaching --
BIO 2306 - Genetics
BIO 4352 - Evolutionary Developmental Genetics
BIO 5311: Advanced Genetic Analysis
Genetic Analysis of Cell Polarity in Drosophila Photoreceptor
Cell Polarity is a feature common to many cell types. Cell polarity is mirrored by the asymmetric distribution of intracellular components along a particular axis. Cell polarity also can provide positional information in multicellular pattern formation. Therefore, the cell polarity is crucial for morphogenesis and development. Because photoreceptors are highly polarized as the light-sensing organs, therefore, we are investigating molecular genetic mechanisms that control cell polarity and morphogenesis of Drosophila photoreceptors.
The current research subjects include: 1) To elucidate how cell polarity genes contribute to dynamic cell morphogenetic processes, such as photoreceptor elongation, during morphogenesis. 2) To investigate the molecular genetic basis of how cell polarity is established and regulated in photoreceptors. To conduct these studies, we employ a variety of molecular, cellular, and genetic technologies, and use Drosophila as material. We use Drosophila because of the variety of sophisticated genetic and molecular tools available. Our long-term goal is to shed light on the genetic mechanisms of the cell polarity in organ development, morphogenesis, and pattern formation.
Uyen Ngoc Mui, Christina M Lubczyk,Sang-Chul Nam* (2011) Role of Spectraplakin in Drosophila photoreceptor morphogenesis. PLoS ONE 6(10):e25965.
Garrett P League, Sang-Chul Nam* (2011) Role of Kinesin heavy chain in Crumbs localization along the rhabdomere elongation in Drosophila photoreceptor. PLoS ONE, 6(6); e21218.
Geng Chen, Alicia K Rogers, Garrett P League and Sang-Chul Nam* (2011) Genetic interaction of Centrosomin and Bazooka in apical domain regulation in Drosophila photoreceptor. PLoS ONE 6(1): e16127.
Bibhash Mukhopadhyay, Sang-Chul Nam and Kwang-Wook Choi (2010) Kinesin-II is required for cell survival and adherens junction positioning in Drosophila photoreceptors. Genesis 48(9): 522-530.
Geng Chen, Garrett P. League, Sang-Chul Nam* (2010) Role of Spastin in apical domain control along the rhabdomere elongation in Drosophila photoreceptor. PLoS ONE 5(3), e9480.
Tony W. Chen, Geng Chen, Lisa J. Funkhouser, Sang-Chul Nam* (2009)Membrane domain modulation by spectrins in Drosophila photoreceptor morphogenesis. Genesis 47(11), 744-750.
Kwang-Wook Choi, Sang-Chul Nam, Bibhash Mukhopadhyay, (2007) Par-1 and PP2A: Yin-Yang of Bazooka Localization. Fly 1(4), 235-237.
Sang-Chul Nam, Bibhash Mukjopadhyay, Kwang-Wook Choi (2007) Antagonistic function of Par-1 kinase and protein phosphatase 2A are required for localization of Bazooka and photoreceptor morphogenesis in Drosophila. Developmental Biology 306, 624-635.
Sang-Chul Nam and Kwang-Wook Choi (2006) Domain-specific early and late function of Dpatj in Drosophila photoreceptor cells. Developmental Dynamics 235, 1501-1507.
Sang-Chul Nam and Kwang-Wook Choi (2003) Interaction of Par-6 and Crumbs complexes is essential for photoreceptor morphogenesis in Drosophila. Development 130, 4363-4372.
Shayan Izaddoost, Sang-Chul Nam, Manzoor A. Bhat, Hugo J. Bellen and Kwang-Wook Choi (2002) Drosophila Crumbs is a positional cue in photoreceptor adherens junctions and rhabdomeres. Nature 416, 178-183.
Sang-Chul Nam and Changwon Kang (2005) DNA light-strand preferential recognition of human mitochondria transcription termination factor mTERF. J. Biochem. Mol. Biol. 38, 690-694.
Sang-Chul Nam and Changwon Kang (2001) Expression of cloned cDNA for the human mitochondrial RNA Polymerase in E. coli and purification. Protein Expr. Purif. 21, 485-491.
Sang-Chul Nam and Changwon Kang (1988) Transcription initiation site selection and abortive initiation cycling of phage SP6 RNA polymerase. J. Biol. Chem. 263, 18123-18127.