|Baylor > Environmental Science > Faculty and Staff > Christie M. Sayes, Ph.D.|
- Program Director, Environmental Health Sciences - Emerging Technologies, RTI International
- Adjunct Professor with the Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University
- Adjunct Professor with the Department of Biomedical Engineering, Texas A&M University
- Adjunct Professor with the Department of Nanoscience, Joint School, University of North Carolina – Greensboro
- Adjunct Professor with the Department of Environmental Science, Baylor University
- President of the North Carolina Chapter of the Society of Toxicology
- Ph.D., Chemistry, Rice University, Houston, TX
- M.S., Chemistry, Rice University, Houston, TX
- B.S., Chemistry, Louisiana State University, Baton Rouge, LA
Academic and Research Interests
Dr. Christie M. Sayes is senior scientist and program director for the Environmental Health Sciences – Emerging Technologies Group at RTI International. She was formerly a professor of toxicology at Texas A&M University. Dr. Sayes maintains her adjunct faculty appointment at Texas A&M in the Department of Biomedical Engineering and the Interdisciplinary Program in Toxicology. She has more than a decade of experience in the fields of nanotechnology and nanotoxicology and has authored numerous publications, including original research, invited reviews and book chapters. She is a member of the Society of Toxicology, the American Chemical Society, and the Society of Environmental Toxicology and Chemistry. She serves on the Editorial Board of the journals Toxicological Sciences, Nanotoxicology, and Toxicology Letters. Recently, Christie was elected President of the North Carolina Chapter Society of Toxicology.
Sayes has proven abilities in providing technical guidance and leadership to students, technicians, and colleagues; a high aptitude for development of complex particle toxicological and biocompatibility basic and applied research projects in cell culture based and animal based models; substantial training in nanomaterial & nanotoxicology research techniques & instruments; significant experience working independently & collaborating across disciplines and organizations; excellent communication and interpersonal skills with colleagues in science and engineering, senior management, and new and existing clients and other funding sources.
The goal of the research performed in her laboratory is to investigate the fate, transformation, and biological effects of nanoparticles and nanomaterial systems. Her group addresses several fundamental issues relevant to the development safe and effective nanomaterials in biological and environmental applications. These issues include, but are not limited to, the following parameters: the importance of material characterization, dose-response & time-course, correlation of in vitro findings to in vivo results, mechanistic & synergistic analyses, developing mathematical and computational models for predicting nanoparticle toxicities, and defining appropriate endpoints in hazard identification and exposure conditions for risk evaluation.
Recent Published Works:
Sayes CM, Heidel D, Schulte P, Hodson, L, and Geraci G. (2014). “Safe Nano Design: Molecule to Manufacturing to Market: Responsible Practices for Safe Nano Design“. Journal of Nanoparticle Research.
Bartlett JA, Brewster M, Brown P, Cabral-Lilly D, Cruz CN, David R, Eickhoff WM, Haubenreisser S, Jacobs A, Malinoski F, Morefield E, Nalubola R, Prud’homme R, Sadrieh N, Sayes CM, Shahbazian H, Subbarao N, Tamarkin L, Tyner K, Uppoor R, Whittaker-Caulk M, Zamboni W. (2014). “Summary report of PQRI Workshop on Nanomaterial Drug Products: Current
Experience and Management of Potential Risks”. The AAPS Journal.
Powers CM, Grieger KD, Beaudrie C, Hendren CO, Davis JM, Wang A, Sayes CM, MacDonnell M, Gift JS. (2014). “Data dialogues: critical connections for designing and implementing future nanomaterial research”. Environment Systems and Decisions.
Sayes CM, Staats H, Hickey AJ. (2014). “Scale of Health: Indices of Safety and Efficacy in the Evolving Environment of Large Biological Datasets”. Pharmaceutical Research.
Sooresh A, Pine M, Sayes CM. (2014). “Effects of a novel pesticide-particle conjugate on viability and reactive oxygen species generation in neuronal (PC12) cells”. Drug and Chemical Toxicology.
Sayes CM. (2014). “The relationships among structure, activity, and toxicity of engineered nanoparticles”, KONA Powder and Particle Journal 31:10.
Romoser AA, Criscitiello MF, Sayes CM. (2014). “Engineered nanoparticles induce DNA damage in primary human skin cells, even at low doses”, Nano LIFE 4(1):1-13.
Dellinger A, Zhou Z, Connor J, Madhankumar AB, Pamujula S, Sayes CM, Kepley CL. (2013). “Application of fullerenes in nanomedicine: an update”, Nanomedicine 8(7):1191–1208.
Berg JM, Romoser AA, Figueroa DE, West CS, and Sayes CM. (2013). “Comparative cytological responses of lung epithelial and pleural mesothelial cells following in vitro exposure to nanoscale SiO2.” Toxicology In Vitro, 27(1):24-33.
Hicks JB, McCarthy SA, Mezei G, and Sayes CM. (2011). “Ultrafine Particles at Coal and Gas Fired Power Plant Work Areas.” Annals of Occupational Hygiene, 56(2):182-193.
Sayes CM and Ivanov I; (2010) “Comparative Study of Predictive Computational Models for Nanoparticle-Induced Cytotoxicity”. Risk Analysis, 30(11):1723.