Student Research Examples (SWURP)


Caitlyn Brashears

STEAM (A Study of Sequential and Concurrent FOLFXIRI/Avastin vs. FOLFOX/Avastin in First-Line in Patients with Metastatic Colorectal Cancer) at the Cancer Center under the instruction of Sarah Allenson

The STEAM study was designed and organized my Genentech-Roche. "This randomized, open-label, multicenter study will evaluate the efficacy and safety of FOLFOXIRI/Avastin (bevacizumab) regimens (concurrent and sequential) versus FOLFOX/Avastin in first-line in patients with metastatic colorectal cancer. Patients will be randomized to receive Avastin 5 mg/kg intravenously every 2 weeks with either concurrent or sequential FOLFOXIRI or with FOLFOX for 4 to 6 mont hrs of induction therapy, followed by maintenance therapy with Avastin plus either leucovorin/5-fluorouracil or capecitabine until disease progression occurs. After disease progression, patients will receive treatment with a fluoropyrimidine-based chemotherapy plus Avastin."

Audrey Eichenberger

Project P.R.E.V.E.N.T. Behavioral Health Services Utilization in First Responders Survey Analysis

Commonly exposed to horrific events and traumatic stressors, firefighters are prone to developing mental health disorders, such as Posttraumatic Stress Disorder (PTSD), depression, and anxiety. For example, a study revealed that approximately one-fifth of protective service workers that responded to Hurricane Katrina experienced symptoms of PTSD and more than a quarter reported symptoms of depression (CDC, 2005). Rather than seek out behavioral health services, such as employee assistance programs (EAPs), Members Assistance Programs (MAPS), and counseling and mental health services, emergency responders often turn to avoidance, denial, and repression (Witztum & Malkinson, 1998). Although the absence of social support following a stressful event has been indicated as the largest risk factor for PTSD (Brewin, Andrews, & Valentine, 2000), numerous barriers exist that hinder the utilization of behavioral health services. Because stigma, cost, and lack of information about behavioral health services often prevent such services from being wholly effective, the components important for success were investigated by the Texas A&M/IAFF Partnership for the Study of Implementation of State-of-the-Art Behavioral Health Programs into Fire Service Culture, Project P.R.E.V.E.N.T. (Pulling Rescue Emergency Volunteer & Employee Needs Together). A FY 2007 Fire and Safety Proposal was designed to study the shortcomings in adoption and implementation of behavioral health programs across fire service, and, to learn about the current state of behavioral health in departments across the country, Project P.R.E.V.E.N.T. conducted 20 focus groups with emergency responders of different ranks and experiences. Based off of these focus groups, two surveys were developed: an online survey that reached fire fighters through the International Association of Fire Fighters (IAFF) website and a mailed-out survey, which reached volunteer departments through the International Association of Fire Chiefs (IAFC). The results of these surveys revealed the barriers to effective behavioral health programs and the means that are necessary to promote behavioral health programs. Based on the data, efforts to de-stigmatize behavioral health services are called for.

Matthew Grimsbo

Predictors of Limitations in Parkinson's Disease

Parkinson’s disease is characterized, most commonly as, a movement disorder caused by the neurodegeneration of the central nervous center. The disease has been known to cause motor deficiencies such as tremors, decreased speed of motor movements, and rigidity. The non-motor functions can also be effected causing loss in smell, decline in cognitive abilities, changes in mood, and problems with sleep. The non-motor symptoms of Parkinson’s have been shown to be a better determinate for health related quality of life than the motor expressions of the disease. Functional independence is also an important patient centered outcome, because it effects caregiver burden as well as the social economic burden. So, this study hopes to help clarify the non-motor symptoms of Parkinson’s which correlate to functional disabilities and give doctors an empirical set of predictors to base patient treatment plans.

Brittany Ladd

REACT 2 is a study on Crohn's disease that seeks to find a better treatment plan by using a combination therapy administered early

p>REACT 2- Enhanced algorithm that focuses on incorporating the early administration of a combination of drugs with an objective assessment of disease activity in Crohn's patients.Methods are to recruit patients based on exclusion/inclusion criteria, perform the enhanced algorithm on them or allow them to continue their same treatment plan. Study is in beginning stages and has no results yet.

Joyce McRae

Dosimetric and Clinical Analysis of Outcomes and Toxicities for Patients Treated with Adjuvant Chemotherapy and Radiation for Gastric Cancer After Surgical Resection / Enrique Izaguirre

Project 1's Specific Aim: To determine the most optimal radiation technique for planning radiotherapy for gastric cancer in adjuvant setting after surgical resection, develop treatment planning templates to expedite the radiation planning and statistical method for treatment plans comparison and outcome analysis. These patients were followed clinically to assess for outcomes, toxicity, and the adequacy of the treatment plans.

Soraya Naqvi

Doxycycline as an Inhibitor of Hemorrhagic Shock-Induced Hyperpermeability

Doxycycline project - The goal of my project is to see if we can prevent (MMP-9) mediated degradation of adheren junction proteins induced by HS when given a doxycycline pretreatment. If doxycycline prevents hyperpermeability, it may be able to prevent the symptoms associated with hemorrhagic shock.

Aparna Sarode

PROJECT 1: Efficacy and Tolerability of Intravenous Levetiracetam in Children. PROJECT 2: A Double-blind, Randomized, Placebo-controlled, Multicenter, Parallel-group Study with an Open-label Extension Phase to Evaluate the Efficacy and Safety of Adjunctive Perampanel in Primary Generalized Tonic-Clonic (PGTC) Seizures.

The first project was a retrospective study on the use of Keppra for seizure management in children. The second project looked at the alternative use of Perampanel in treating Primary Generalized Tonic-Clonic (PGTC) Seizures.

>Kristen Schemel

PROJECT 1: Endovascular Interventions with Angiomax (ENDOMAX) and PDE-5 Inhibitors. PROJECT 2: Prostate Cancer in Men with Erectile Dysfunction

ENDOMAX: This is a clinical trial that compares the anticoagulants unfractionated heparin and bivalirudin in peripheral endovascular interventions. The aim is to prove that bivalirudin is a more effective drug for the intervention. The primary objective of the study is to demonstrate that anticoagulation with bivalirudin results in fewer major bleeding complications compared with unfractionated heparin in subjects undergoing peripheral endovascular interventions. The secondary objective is to identify potential benefits from bivalirudin therapy on other clinically important events such as death, myocardial infarction (MI), stroke and/or transient ischemic attack (TIA), amputation, unplanned repeat revascularization (URV), and minor bleeding, as well as potential economic benefits that may result from improved clinical outcomes. Endomax is a nationwide, multi-center, double blind, and controlled trial where patients are randomized to either UFH or bivalirudin. PDE-5 Inhibitors and Prostate Cancer in Men with Erectile Dysfunction: The aim of the study is to determine the overall incidence rate of prostate cancer among men with erectile dysfunction (ED) who were treated with PDE-5 inhibitors. The purpose of the study is to demonstrate that PDE-5 inhibitors reduce the risk of prostate cancer in men with ED. This is a single-center study that is being completed by retrospective review of electronic medical records. Data is being collected for five confounding variables: age, ethnicity, PSA levels, if PDE-5i use was continuous, if they smoke, and if they have diabetes.

Ryan Shephard

Neurologic presentations of intravascular lymphoma: a 643

Neurologic complications are frequently seen in cases of intravascular lymphoma (IVL), however the full spectrum and frequency with which these symptoms are seen has not been characterized. A comprehensive meta-analysis of 654 cases of IVL published between 1957 and 2012 was performed to provide better insight into the neurologic presentations of this disease. Neurologic complications were divided into central nervous system (CNS) symptoms and peripheral nervous system (PNS) symptoms. CNS symptoms were seen in 42% of all cases. The most common being cognitive impairment/dementia (60.9%), paralysis (22.2%), and seizures (13.4%). PNS complications were seen in 9.5% of cases while muscle weakness/numbness (59.7%), neurogenic bladder (37.1%), and paresthesias (16.1%) were the most common symptoms. Neurologic complications of IVL present with a broad spectrum of symptoms and represent a large source of morbidity in patients with intravascular lymphoma.

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