Irene Caufield Cobb was born on October 26, 1909, to Thomas J. and Emma Caufield. She attended A.J. Moore High School in Waco and then studied at Langston University and Samuel Huston College. She took graduate courses at Baylor University, earning teaching certificates in elementary education and home economics. She married Eddie Cobb, Jr. in 1930, and the couple had three daughters. Cobb taught in Waco area schools for 31 years and was involved in several community organizations, including the North Sixth Street Community Club. She was a member of New Hope Baptist Church in Waco. Other community activities include the People's Cemetery Association, Young Women's Christian Association, McLennan County Retired Teachers' Association, and Sigma Gamma Rho sorority. She also did a significant amount of research on her family's genealogy. Cobb died on March 14, 1989.
More information about Irene Caufield Cobb can be found in the Irene Cobb papers at The Texas Collection.