Biotransformation is the chemical modification (or modifications) made by an organism on a chemical compound, often associated with change (increase, decrease, or little change) in pharmacologic and toxicologic activity. Research in our department examines multiple aspects of biotransformation of pollutants in hepatic and extra-hepatic metabolism. Extensive efforts are made to thoroughly investigate the metabolism of compounds that can alter pharmacokinetic parameters like bioavailability, drugs or pollutants interactions, and elimination in living organisms.