The overarching focus of research performed in my laboratory is answering a variety of mechanistic toxicological questions relating to insult, injury, and healing of human systems. My area of major interest is in areas relating to hypoxia-induced medical conditions occurring from insults, injury, or exposures to environmental contaminates and pharmaceuticals (i.e., traumatic brain injury (TBI), burns, cancer, chronic wound healing). The role that the environment plays in human health and subsequent healing following the aforementioned insults or injuries is of significant interest. Our investigations focus on the cellular mechanisms of toxic action/healing and the mechanisms of uptake for nanomedicine applications to treat these hypoxia-induced conditions. Areas of ongoing research includes developing nanomedicine interventions to reverse hypoxia in situ, evaluating environmental contribution to hypoxia-induced conditions (e.g. human health risk assessment), using quantitative structure-activity (QSAR) modeling for drug design, and evaluating mechanistic biological responses, that play a role in healing, from exposures to environmental contaminants and pharmaceuticals.