|Date||November 15, 2013|
|Time||3:30 - 5:00 pm|
|Description||New Approaches to Complex Carbohydrates and Quaternary Nitrogen-Containing Molecules"|
We have developed new approach for the effective synthesis of 1,2-cis-2-aminosugars via nickel-catalyzed selective glycosylation. These sugars not only make up one of the most important classes of oligosaccharides and glycoconjugates but are also one of the challenging glycosidic bonds found in nature. In general, obtaining an adequate supply of these sugars from natural sources is exceedingly challenging. The methods that are being developed in our group are broadly applicable and provide products in high yield and with excellent levels of anomeric selectivity. Our nickel-catalyzed 1,2-cis-2-amino glycosylation methods are applied to the synthesis of bioactive carbohydrate molecules such as heparin oligosaccharides, mycothiol, GPI anchors, and mucin O-glycans.
Our second program is to develop novel methodologies for the regio- and enantioselective preparation of branched allylic fluorides and nitrogen-containing quaternary and tertiary centers via transition metal catalyzed dynamic kinetic asymmetric transformations of racemic secondary and tertiary allylic trichloroacetimidates.
Refreshments served 3:00 - 3:25pm.
Dr. Nguyen - University Of Iowa
|Publisher||Baylor Sciences Building|
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