Dennis A. Johnston, Ph.D.
Professor of Statistical Science
Ph.D., Mathematical Analysis and Mathematical Statistics, Texas Tech University, 1971
M.A., Mathematical Analysis and Mathematical Statistics, University of Texas, 1966
B.S., Mathematics & Physics, Arlington State College, 1965
Major area of research
Mathematical Statistics, Biostatistics
Courses currently teaching
5364 Survival and Reliability Theory
5365 Design of Experiments and Clinical Trials
5366 Statistical Bioinformatics
5383 Multivariate Statistics Analysis
5384 Multivariate Statistical Methods
After my graduate work and during military service with the U.S. Army, I was stationed at the Johnson Spacecraft Center where I worked on a number of projects (moon rock analysis, powder diffraction patterns, earth observations, management questionnaire assessment). After military service, I worked for 31 years for The University of Texas M.D. Anderson Cancer Center also in Houston, Texas as a biostatistician. Over this period I helped develop automated and semi-automated analysis of unbanded and banded, metaphase and prophase cell preparations; flow cytometry analysis; analysis of two-dimensional electrophoresis gels; imaging, classification and analysis of stained nuclei as it effects diagnosis and treatment of disease; analysis and comparison of radiographic diagnosis; analysis of prostate cancer progression and simulation of diagnostic methods; analysis and genetic mapping of bladder cancer; analysis of the progression of disease in pediatric cancer patients using minimum residual disease markers.
I retired from U.T. M.D. Anderson Cancer Center in 2004 and came to Baylor University to devote time to teaching statistical methods and training new statisticians. Personally, my wife Janice and I are active members at the Antioch Community Church, in a Life Group there, teach in the training school, and go on missions during the year. I love playing guitar and we regularly play at nursing homes both here and in Ireland. I enjoy golf and reading.
Reid, A., Warner, J., Ridley, W., Johnston, D., Harmon, R., Jakes, P., and Brown, R. The major element compositions of lunar rocks as inferred from glass compositions in the lunar soils. Proceedings of the Third Lunar Science Conference (Supplement 3, Geochimica et Cosmochimica Acta) 1:363-378, The MIT Press, 1972.
Chaturvedi, V., Li L., Hodges, S., Johnston, D.A., Ro, J.Y, Logothetis, C., von Eschenbach, A.C., Batsakis J.G., Czerniak B. Superimposed histologic and genetic mapping of chromosome 17 alterations in human urinary bladder neoplasia. Oncogene 14:2059-2070, 1997.
Chen, M.E., Troncoso, P. Johnston, D.A., Tang, K. and Babaian, R.J. Optimization of prostate biopsy strategy using computer based analysis. Journal of Urology 158: 2168-2175, 1997.
Oshiro, V., Chaturvedi, V., Hayden, D., Nazeer, T., Johnson, M., Johnston, D.A., Ordˇ˝ez, N.G., Ayala A.G., Czerniak B. Altered p53 is associated with aggressive behavior of chondrosarcoma: A long-term follow-up study. Cancer, 83:2324-2334, 1998.
Soliman A.S., Bondy M.L., Raouf A.A., Makram M.A., Johnston D.A., and Levin G. Cancer mortality in Menofeia, Egypt: comparison with US mortality rates. Cancer Causes & Control, 10(5):349-54, 1999.
Czerniak, B., Chaturvedi, V., Li, L., Hodges, S., Johnston D, Ro JY, Luthra R, Pugh WC, Logothetis C, von Eschenbach AC, Grossman B, and Batsakis JG. Superimposed histologic and genetic mapping of chromosome 9 in progression of human urinary bladder neoplasia: implications for a genetic model of multistep urothelial carcinogenesis and early detection of urinary bladder cancer. Oncogene, 18:1185-1196, 1999.
Van Kleef, E.M., Zurcher, C., Oussoren, Y.G., Te Poele, J.A.M., van der Valk, M.A., Niemer-Tucker, M.M.B., van der Hage, M.H., Broerse, J.J., Robbins, M.E.C., Johnston, D.A., and Stewart, F.A.: Long-term effects of total-body irradiation on the kidney of Rhesus monkeys. International Journal of Radiation Biology 76,5:641-648, 2000.
Kuniyasu, H., Troncoso, P., Johnston, D., Corazon, D.B., Tahara, E., Fidler, I.J. and Pettaway, C.A.: Relative expression of type IV collagenase, E-cadherin, and vascular endothelial growth factor/vascular permeabilty factor in prostatectomy specimens distinguishes organ-confined from pathologically advanced prostate cancers. Clinical Cancer Research, 6:2295-2308, 2000.
Chen, M.E., Johnston, D.A., Tang, Kuang, Babaian, R.J. and Troncoso, P.: Detailed mapping of prostate carcinoma foci. Cancer, 89:1800-1809, 2000.
Bao, H-J., Lee, B.P., Stephens,L.C., Sahin, A.A., Van, N.T., Johnston, D.A., Ou, C-N. and Kuo, M.T.: Elevated expression of hepatic proliferative markers during early hepatocarcinogenesis in hepatitis-B virus transgenic mick lacking mdr1a-encoded P-Glycoprotein. Molecular carcinogenesis 29:103-111, 2000.
Czerniak, B., Li, L., Chaturvedi, V., Ro, J.Y., Johnston, D.A, Hodges, S., and Benedict, W.F.: Genetic modeling of human urinary bladder carcinogenesis. Genes, Chromosomes & Cancer 27:392-402. 2000.
Kazianis, S., Coletta, L.D., Morizot, D.C., Johnston, D.A., Osterndorff, E.A., and Nairn, R.S. Overexpression of a fish CDKN2 gene in a hereditary melanoma model. Carcinogenesis, 21(4):599-605, 2000.
Ruifrok, A.C. and Johnston, D.A.: Quantification of histochemical staining by color deconvolution. Analytical and Quantitative Cytology and Histology 23,4:291-299, 2001.
Kram, A., Li, L., Zhang, R.D., Yoon, D.S., Ro, J.Y., Johnston, D.A., Grossman, H.B., Scherer, S. and Czerniak, B.: Mapping and genome sequence analysis of chromosome 5 regions involved in bladder cancer progression. Laboratory Investigation 81,7:1039-1048, 2001.
Yoon, D-S, Li, L., Zhang, R.D., Kram, A., Ro, J.Y., Johnston, D.A., Grossman, H.B., Scherer, S. and Czerniak, B. Genetic mapping and DNA sequence-based analysis of deleted regions on chromosome 16 involved in progression of bladder cancer from occult preneoplastic conditions to invasive disease. Oncogene, 20:5005-5014, 2001.
Babaian, R.J., Troncoso P., Bhadkamkar V.A., and Johnston, D.A. Analysis of clinicopathologic factors predicting outcome after radical prostatectomy. Cancer, 91(8):1414-22, 2001.
Babaian, R.J., Johnston, D.A., Naccarato W., Ayala A., Bhadkamkar V.A., Fritsche H.A. The incidence of prostate cancer in a screening population with a serum prostate specific antigen between 2.5 and 4.0 ng/ml: relation to biopsy strategy. Journal of Urology, 165(3):757-60, 2001.
Ruifrok, A.C. and Johnston, D.A. Quantification of histochemical staining by color deconvolution. Analytical and Quantitative Cytology and Histology, 23(4):291-299, 2001.
Mian, B.M., Troncoso P., Okihara K, Bhadkamkar V, Johnston D., Reyes A.O., and Babaian R.J. Outcome of patients with Gleason score 8 or higher prostate cancer following radical prostatectomy alone. Journal of Urology, 167, 1675-1680, 2002.
Fizazi, K., Martinez, L.A., Sikes, C.R. Johnston, D.A., Stephens, L.C. McDonnell, T.J., Logothetis, C.J., Trapman, J., Pisters, L.L., Ordonez, N.G., Troncoso, P. and Navone, N.M. The association of p21((WAF-1/CIP1)) with progression to androgen-independent prostate cancer. Clinical Cancer Research, 8(3):775-781, 2002.
Okihara, K., Cheli, C.D. Partin, A.W., Fritche, H.A., Chan, D.W., Sokoll, L.J., Brawer, M.K., Schwartz, M.K., Vessella, R.L., Loughlin, K.R., Johnston, D.A. and Babaian, R.J. Comparative analysis of complexed prostate specific antigen, free prostate specific antigen and their ratio in detecting prostate cancer. Journal of Urology. 167(5):2017-2023; discussion 2023-2024, 2002.
Sen, S., Zhou, H., Zhang, R.D., Yoon, D.S., Vakar-Lopez, F., Ito, S., Jiang, F., Johnston, D., Grossman, H.B., Ruifrok, A.C., Katz, R.L., Brinkley, W., Czerniak, B. Amplification/overexpression of a mitotic kinase gene in human bladder cancer. J. Natl. Cancer Inst. 94(17):1320-1329, 2002.
Rong, X.J., Shaw, C.C., Johnston, D.A., Lemacks, M.R., Liu, X., Whitman, M.D., Stephens, T., Thompson, S.K., Krugh, K.T.Stephen K. Thompson, and Lai, C-J. Microcalcification detectability for four mammographic detectors: flat-panel, CCD, CR, and screen film. Medical Physics 29(9): 2052-2061.
Zipf, T. F., Johnston, D.A. (eds.): Leukemia and Lymphoma: Detection of Minimal Residual Disease, Humana Press, 2003.
Rudd, M.D., Johnston, D.A., Kazianis, S. and Butler, A.P. Cloning and analysis of a FoxO transcription factor from Xiphophorus. Gene. 302(1-2):31-41, 2003.
Kuniyasu, H., Ukai, R., Johnston, D.A., Troncoso, P., Fidler, I.J., Pettaway, C.A.. The Relative mRNA Expression Levels of Matrix Metalloproteinase to E-cadherin in Prostate Biopsy Specimens Distinguishes Organ-Confined from Advanced Prostate Cancer at Radical Prostatectomy. Clinical Cancer Research. 9: 2185-2194,2003.
Ruifrok, A.C., Katz, R.L., and Johnston, D.A. Comparison of quantification of histochemical staining by hue-saturation-intensity (HIS) transformation and color-deconvolution. Appl. Immunohistochem Mol Morphol. 11 (1): 85-91, 2003.
C.-J. Lai, C. C. Shaw, G. J. Whitman, D. A. Johnston, W. T. Yang, V. Selinko, E. Arribas, B. Dogan, S. C. Kappadath, "Visibility of simulated microcalcifications - A hardcopy-based comparison of three mammographic systems," Medical Physics, 32(1), p.182-194, 2005.
Kiat-amnuay, S., Johnston, D.A., Powers, J.M., and Jacob, R.F.: Color Stability of Dry Earth Pigmented Maxillofacial Silicone A-2186 Subjected to Microwave Energy Exposure. J Prosthodont. 14:91-6. 2005.
Adams R.P., Nguyen S., Johnston D.A., Park S., Provin T.L., Habte M., and Dafforn M.R. Comparison of vetiver root essential oils from cleansed (bacteria- and fungus-free) versus non-cleansed (normal) plants. Biochemical Systematics and Ecology, 36(3): 177-182, 2008.
Kiat-amnuay, S., Jacob, R.F., Chambers, M.S., Anderson, J.A., Sheppard, R.A., Johnston, D.A., Haugh, G.S., and Gettleman, L.: Clinical Trial of Chlorinated Polyethylene for Facial Prosthetics. Int. J. Prosthodont. 23(3):263-270, 2010 May-Jun.