He moved to Tyler, Texas, in 1920 where he attended Tyler High School and Tyler Junior College. He excelled in academics, and his artistic talent flourished. From 1922 to the 1930's, Nash joined his father in the sign-painting business in Tyler where they worked day and night. His skill at doing gold-leaf printing was in high demand. He also was generous with his lettering and drawing skills by producing signs for church or charity bazaars.
During this time, Nash continued to draw cartoons. He won many awards and cash prizes but remained humble and focused on the art of cartooning. He took another correspondence course and attended the University of Texas at Austin and the Art Institute of Chicago.
Nash began working at the Tyler Courier-Times in 1936. He split his time between drawing cartoons and operating the electronic engraving machines. His career was interrupted by a period of service in World War II, where he was sought out for his talent drawing maps and signs.
When the war ended, Nash returned to his editorial cartooning post with the Tyler paper. It was at this time that Nash's best remembered character, Old Man Tyler, emerged. Old Man Tyler was a symbol of the city's leaders and always had an opinion about hot city issues.
Sam Nash died in 2000 after a long life and a celebrated career.