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DTSTAMP:20260609T090912Z
SUMMARY:Possible Functions of Tubulin Isotypes Dr. Richard F. Ludueña Professor of Biochemistry University of Texas Health Sci. Center, San Antonio
DESCRIPTION;ENCODING=QUOTED-PRINTABLE:ABSTRACT:  Tubulin, the subunit protein of microtubules, is an alpha/beta heterodimer.  In vertebrates, both alpha- and beta-tubulin exist as multiple isotypes differing in amino acid sequence and encoded by different genes.  We have focused on the isotypes of beta-tubulin.  The differences among the beta-tubulin isotypes are highly conserved in evolution, suggesting that they are functionally significant.  We have used a variety of approaches to explore the specific functions of five of the six major beta-tubulin isotypes.  We have found that, in addition to the canonical functions of forming the interphase network and the mitotic spindle, each isotype appears to have a specific separate function, some of which we may have identified.  Our findings are very relevant to the design of anti-tumor drugs.  The possible functions of the isotypes and their potential roles in cancer chemotherapy will be discussed.=0D=0A=
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For additional information contact Mrs. Barbara Rauls, 710-4926=0D=0A=
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LOCATION:BSB C-105
DTSTART;TZID=US_Central:20121109T153000
DTEND;TZID=US_Central:20121109T170000
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