Washington University, St Louis, MO - 2004
Calvin College, Grand Rapids, MI - 1992
Washington University, St. Louis, MO - 2004-2006
Washington University, St. Louis, MO - 2006-2011
Assistant Professor of Biochemistry
Baylor University - 2011-present
My laboratory focuses on the investigation of host-pathogen interactions and metabolic changes associated during the infection to provide insights into the molecular mechanisms of microbial pathogenesis, thereby facilitating the development of novel therapeutic agents for the treatment and the prevention of infectious disease. The structural characterization of host-pathogen interactions in vivo involving cell surfaces is difficult due to the complexity and heterogeneity, making it incompatible with the conventional structural methods such as x-ray diffraction and solution-state NMR. Our approach is to use combined solid-state NMR and LC-MS to provide structural insights with atomic resolution and the changes in chemical and metabolic compositions during the infection.
Combined solid-state NMR and biophysical methods are used to characterize the chemical compositions and structures of complex biological solids. Some of research interests include i) structural characterization of antimicrobial cyclic peptide binding sites in Gram-positive pathogens, S. aureus and E. faecalis, ii) compositional analysis of extracellular matrices of bacterial cell surface, and iii) carbon-flux analysis for lipid biosynthesis in green alga Chlamydomonas reinhardtii.